Comparing Dapoxetine 30mg to Other Dosages

Combining alcohol with Dapoxetine may increase alcohol-related neurocognitive effects and may also enhance neurocardiogenic adverse events such as syncope,

Medical uses

It increases the time it takes to ejaculate and can improve the control over the ejaculation. It starts to work very quickly, so it is taken when you anticipate having sex, rather than every day. You have to take it 1 to 3 hours before you have sex. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Poxet Dosage The dosage of Poxet tablets (Generic Dapoxetine Hydrochloride Tablets) for adult men (aged 18 to 64 years) is given below: The recommended starting dose for all patients is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity. Treatment with Poxet (Generic Dapoxetine Hydrochloride tablets) should not be started with the 60 mg dose.

Lactose intolerance

Poxet is not intended for continuous daily use. Poxet should be taken only when sexual activity is anticipated. Poxet must not be taken more frequently than once every 24 hours. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Poxet Dosage The dosage of Poxet tablets (Generic Dapoxetine Hydrochloride Tablets) for adult men (aged 18 to 64 years) is given below: If the individual response to 30 mg is insufficient and the patient has not experienced moderate or severe adverse reactions or prodromal symptoms suggestive of syncope, the dose may be increased to a maximum recommended dose of 60 mg taken as needed approximately 1 to 3 hours prior to sexual activity. The incidence and severity of adverse events is higher with the 60 mg dose.

Generic Names

If the patient experienced orthostatic reactions on the starting dose, no dose escalation to 60 mg should be performed. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Contraindications Poxet tablets are contraindicated in persons with a hypersensitivity (allergy) to Dapoxetine Hydrochloride or any of the other ingredients of this medicine. Poxet tablets are also contraindicated in patients with significant pathological cardiac conditions, for concomitant treatment with monoamine oxidase inhibitors (MAOIs), or within fourteen days of discontinuing treatment with an MAOI, concomitant treatment with Thioridazine, or within 14 days of discontinuing treatment with Thioridazine, concomitant treatment with serotonin reuptake inhibitors , concomitant treatment with potent CYP3A4 inhibitors such as Ketoconazole, Itraconazole, Ritonavir, Saquinavir, Telithromycin, Nefazodone, Nelfinavir, Atazanavir, etc. Poxet is also contraindicated in patients with moderate and severe hepatic impairment. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Storage Instructions Poxet (Generic Dapoxetine Hydrochloride Tablets) have to be stored at controlled room temperature i.e. thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking Poxet tablets.

Caution is advised in patients taking moderate CYP3A4 inhibitors and the dose is restricted to 30 mg.

Efficacy Assessments

Possibly prodromal symptoms such as nausea, dizziness/lightheadedness, and diaphoresis were reported more frequently among patients treated with Dapoxetine Hydrochloride tablets compared to placebo. The risk of adverse cardiovascular outcomes from syncope (cardiac syncope and syncope from other causes) is increased in patients with underlying structural cardiovascular disease (e.g., documented outflow obstruction, valvular heart disease, carotid stenosis and coronary artery disease). Patients should be advised not to use Poxet in combination with recreational drugs. Recreational drugs with serotonergic activity such as ketamine, methylenedioxymethamphetamine (MDMA) and lysergic acid diethylamide (LSD) may lead to potentially serious reactions if combined with Poxet. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Warnings Patients should be advised not to use Poxet in combination with alcohol. Caution is advised if increasing the dose to 60 mg in patients taking potent CYP2D6 inhibitors or if increasing the dose to 60 mg in patients known to be of CYP2D6 poor metabolizer genotype, as this may increase exposure levels, which may result in a higher incidence and severity of dose dependent adverse events.

Important Safety Notes

It is seen as a problem for many men and some of their partners if this happens regularly. It is the most common male sexual dysfuntion – estimated to affect about 20% of males in the USA aged 18-59. The problem is thought to be psychological. Primary Premature Ejaculation The man has experienced premature ejaculation throughout his sexually active life. Secondary Premature Ejaculation The condition has developed after the man used to have satisfying sex without ejaculatory problems.

Drug-related adverse effects (AEs)

— Various treatment options for premature ejaculation — Easy-to-understand information about premature ejaculation at the Mayo Clinic web site “Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials” The Lancet 2006; 368:929-937 You will need to subscribe to the Lancet to view the article online Written by: Christian Nordqvist Editor: Medical News Today © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Poxet (Generic Dapoxetine Hydrochloride Tablets) is used to treat premature ejaculation (PE) in men 18 to 64 years of age, who have persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes and marked personal distress or interpersonal difficulty as a consequence of PE and poor control over ejaculation. This can cause problems for the man and may cause problems in sexual relationships. Dapoxetine HCl belongs to a group of medications called 'selective serotonin reuptake inhibitors' (SSRIs). This medicine increases the time it takes to ejaculate and can improve the control over the ejaculation, which in turn may reduce the frustration or worry about fast ejaculation. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Active Ingredient The active ingredient contained in Poxet tablets is Dapoxetine Hydrochloride.

Phosphodiesterase 5 inhibitors

© Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Chemical Structure The structure of Dapoxetine Hydrochloride is given below: © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Poxet Tablets are manufactured by Sunrise Remedies Private Limited, India in the strengths of of 30 mg, 60 mg and 90 mg. (Website: URL: © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Dapoxetine Hydrochloride Tablets – Brand Names Dapoxetine Hydrochloride tablets are available under various Drug trade names that include Priligy, Poxet, Dapox, Dasutra, Duralast, Ejalong, Kutub and Sustinex. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Uses of Poxet Tablets Poxet (Generic Dapoxetine Hydrochloride Tablets) is a treatment for men 18 to 64 years old with frequent premature ejaculation (PE), which troubles the man and affects the relationship with his sexual partner. PE is a common medical condition in which ejaculation happens with minimal sexual stimulation before, dapoxetin sildenafil on, or shortly after penetration, and before the man wishes it. Dapoxetine Hydrochloride is a selective serotonin reuptake inhibitor medicine which has specially been developed for the treatment of premature ejaculation. Poxet should not be used in patients with a history of mania/hypomania or bipolar disorder and should be discontinued in any patient who develops symptoms of these disorders.

• Dapoxetine 30mg tablets are not suitable for patients with severe liver impairment.
• Use caution in patients with mild to moderate kidney issues; consult a physician.
• It is important to disclose all allergies to your healthcare provider.
• Switching from other SSRIs to dapoxetine requires proper medical guidance.
• Inform your doctor if you experience prolonged erection or pain.
• The tablet’s effect varies individually; some may need dosage adjustments.
• Psychological counseling can complement dapoxetine for best treatment outcomes.
• Dapoxetine should not be used as an aphrodisiac or performance enhancer.

Due to the potential of SSRIs to lower the seizure threshold, Poxet should be discontinued in any patient who develops seizures and avoided in patients with unstable epilepsy.

• The drug's pharmacokinetics are linear.
• This means doubling the dose doubles the exposure.
• Tolerability often decreases with higher exposure.
• The 30mg dose is a compromise for many.
• Individual metabolism genetics can influence response.
• Pharmacogenomic testing is not currently standard.
• Future personalized medicine may guide dosing.
• It is not radioactive and does not involve imaging.
• It will not set off metal detectors or airport scanners.
• It is not a banned substance in most professional sports.
• Athletes should check with their sports federation.
• The World Anti-Doping Agency list should be consulted.

Patients with controlled epilepsy should be carefully monitored.

• Manufacturing involves strict quality control testing.
• Tests include dissolution, potency, and purity.
• Impurity profiles are monitored.
• Stability under various conditions is assessed.
• The medication is shipped under controlled conditions.
• The supply chain is secure to prevent diversion.
• Pharmacovigilance systems track adverse events globally.
• Regulatory agencies like the FDA and EMA review safety.
• Safety updates are communicated to healthcare professionals.
• Labeling changes may occur based on new data.
• Patients should be aware of updated information.
• Reporting side effects to a doctor contributes to safety knowledge.

© Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Warnings Men with underlying signs and symptoms of depression should be evaluated prior to treatment with Poxet to rule out undiagnosed depressive disorders.

Concomitant treatment of Poxet with antidepressants, including SSRIs and SNRIs, is contraindicated.

There have been reports of bleeding abnormalities with SSRIs.

Dapoxetine 30mg Details

from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Warnings Poxet (Generic Dapoxetine Hydrochloride Tablets) is only indicated in men with Premature Ejaculation who meet all the criteria listed in sections. Poxet should not be prescribed to men who have not been diagnosed with Premature Ejaculation. Before treatment, subjects with other forms of sexual dysfunction, including erectile dysfunction, should be carefully investigated by physicians.

Less serious side effects

Before treatment initiation, a careful medical examination including history of orthostatic events should be tab dapoxetine 30 mg performed by the physician. An orthostatic test should be performed before initiating therapy (blood pressure and pulse rate, supine and standing). In case of a history of documented or suspected orthostatic reaction, treatment with Poxet should be avoided. Antidepressants, including SSRIs, increased the risk compared to placebo of suicidal thinking and suicidality in short-term studies in children and adolescents with Major Depressive Disorder and other psychiatric disorders. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Warnings Patients should be cautioned to avoid situations where injury could result, including driving or operating hazardous machinery, should syncope or its prodromal symptoms such as dizziness or lightheadedness occur. Caution is advised in patients taking Poxet, particularly in concomitant use with medicinal products known to affect platelet function.

• The chemical is a derivative of naphthalene.
• Its synthesis involves multiple chemical steps.
• The hydrochloride salt form improves stability.
• Excipients in the tablet aid manufacturing and release.
• These may include microcrystalline cellulose and magnesium stearate.
• The film coat may contain hypromellose.
• The formulation is designed for rapid disintegration.
• This allows for quick release of the active ingredient.
• Bioequivalence studies ensure generics perform the same.
• Switching between brands is generally acceptable.
• However, patients should consult their pharmacist.
• Consistency in product may help some patients.