Important Drug Interactions with Sildenafil Citrate

SILDENAFIL CITRATE TABLETS can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. Do not take SILDENAFIL CITRATE TABLETS if you take any other medicines called "nitrates." Nitrates are used to treat chest pain (angina). A sudden drop in blood pressure can cause you to feel dizzy, faint, or have a heart attack or stroke. Do not take SILDENAFIL CITRATE TABLETS if you take medicines called guanylate cyclase stimulators which include: Riociguat (Adempas®) a medicine that treats pulmonary arterial hypertension and chronic-thromboembolic pulmonary hypertension. Tell all your healthcare providers that you take SILDENAFIL CITRATE TABLETS.

If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took SILDENAFIL CITRATE TABLETS. Ask your doctor if your heart is healthy enough to handle the extra strain of having sex. SILDENAFIL CITRATE TABLETS does not protect you or your partner from getting sexually transmitted diseases, including HIV—the virus that causes AIDS.

• Sildenafil citrate can be combined with lifestyle changes.
• Exercise and weight management improve erectile function.
• Quitting smoking enhances medication effectiveness.
• Reducing alcohol intake minimizes side effects.
• Psychological therapy may support ED treatment.
• Counseling can address underlying emotional issues.
• Regular medical check-ups are recommended.
• Patient education improves safe and effective use.

SILDENAFIL CITRATE TABLETS is a prescription medicine used to treat erectile dysfunction (ED). You will not get an erection just by taking this medicine. SILDENAFIL CITRATE TABLETS helps a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated). SILDENAFIL CITRATE TABLETS is not for use in women or children. It is not known if SILDENAFIL CITRATE TABLETS is safe and effective in women or children under 18 years of age. Who should not take SILDENAFIL CITRATE TABLETS?

3. Downsides

For more information, ask your healthcare provider 50 mg sildenafil price or pharmacist. You may report side effects to FDA at 1-800-FDA-1088. How should I store SILDENAFIL CITRATE TABLETS? Store SILDENAFIL CITRATE TABLETS at room temperature between 68°F to 77°F (20°C to 25°C). Keep SILDENAFIL CITRATE TABLETS and all medicines out of the reach of children.

Biochem/physiol Actions

General information about the safe and effective use of SILDENAFIL CITRATE TABLETS. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use SILDENAFIL CITRATE TABLETS for a condition for which it was not prescribed. Do not give SILDENAFIL CITRATE TABLETS to other people, even if they have the same symptoms that you have. This Patient Information leaflet summarizes the most important information about SILDENAFIL CITRATE TABLETS.

Submit a Review & Earn an Amazon Gift Card

If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about SILDENAFIL CITRATE TABLETS that is written for health professionals. For more information, go to or call 1-800-438-1985 What are the ingredients in SILDENAFIL CITRATE TABLETS? This Patient Information has been approved by the U.S. Food and Drug Administration. Do not take SILDENAFIL CITRATE TABLETS if you: take medicines called nitrates (such as nitroglycerin) use street drugs called "poppers" such as amyl nitrate or amyl nitrite, and butyl nitrate take any medicines called guanylate cyclase stimulators such as riociguat (Adempas) are allergic to sildenafil, as contained in SILDENAFIL CITRATE TABLETS and REVATIO, or any of the ingredients in SILDENAFIL CITRATE TABLETS. See the end of this leaflet for a complete list of ingredients in SILDENAFIL CITRATE TABLETS. What should I tell my healthcare provider before taking SILDENAFIL CITRATE TABLETS?

Before you take SILDENAFIL CITRATE TABLETS, tell your healthcare provider if you: have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve or heart failure have had heart surgery within the last 6 months have low blood pressure, or high blood pressure that is not controlled have had an erection that lasted for more than 4 hours have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia have retinitis pigmentosa, a rare genetic (runs in families) eye disease have ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) have kidney problems or are having kidney dialysis Tell your healthcare provider about all the medicines you take1, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SILDENAFIL CITRATE TABLETS may affect the way other medicines work, and other medicines may affect sildenafil pink pill the way SILDENAFIL CITRATE TABLETS works causing side effects. Especially tell your healthcare provider if you take any of the following: medicines called nitrates (see "What is the most important information I should know about SILDENAFIL CITRATE TABLETS?") medicines called guanylate cyclase stimulators, such as riociguat (Adempas) medicines called alpha blockers such as Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosin mesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin). Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. In some patients, the use of SILDENAFIL CITRATE TABLETS with alpha-blockers can lead to a drop in blood pressure or to fainting. medicines called HIV protease inhibitors, such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase) or atazanavir sulfate (Reyataz) some types of oral antifungal medicines, such as ketoconazole (Nizoral), and itraconazole (Sporanox) some types of antibiotics, such as clarithromycin (Biaxin), telithromycin (Ketek), or erythromycin other medicines that treat high blood pressure SILDENAFIL CITRATE TABLETS contains sildenafil, which is the same medicine found in another drug called SILDENAFIL TABLETS.

What other drugs will affect sildenafil?

SILDENAFIL CITRATE TABLETS can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. Do not take SILDENAFIL CITRATE TABLETS if you take any other medicines called "nitrates." Nitrates are used to treat chest pain (angina). A sudden drop in blood pressure can cause you to feel dizzy, faint, or have a heart attack or stroke. Do not take SILDENAFIL CITRATE TABLETS if you take medicines called guanylate cyclase stimulators which include: Riociguat (Adempas®) a medicine that treats pulmonary arterial hypertension and chronic-thromboembolic pulmonary hypertension. Tell all your healthcare providers that you take SILDENAFIL CITRATE TABLETS.

Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took SILDENAFIL CITRATE TABLETS. Ask your doctor if your heart is healthy enough to handle the extra strain of having sex. SILDENAFIL CITRATE TABLETS does not protect you or your partner from getting sexually transmitted diseases, including HIV—the virus that causes AIDS. SILDENAFIL CITRATE TABLETS is a prescription medicine used to treat erectile dysfunction (ED). You will not get an erection just by taking this medicine.

SMILES string

SILDENAFIL CITRATE TABLETS helps a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated). SILDENAFIL CITRATE TABLETS is not for use in women or children. It is not known if SILDENAFIL CITRATE TABLETS is safe and effective in women or children under 18 years of age. Who should not take SILDENAFIL CITRATE TABLETS? Do not take SILDENAFIL CITRATE TABLETS if you: take medicines called nitrates (such as nitroglycerin) use street drugs called "poppers" such as amyl nitrate or amyl nitrite, and butyl nitrate take any medicines called guanylate cyclase stimulators such as riociguat (Adempas) are allergic to sildenafil, as contained in SILDENAFIL CITRATE TABLETS and REVATIO, or any of the ingredients in SILDENAFIL CITRATE TABLETS. SILDENAFIL TABLETS is used to treat a rare disease called pulmonary arterial hypertension (PAH). SILDENAFIL CITRATE TABLETS should not be used with SILDENAFIL TABLETS or with other PAH treatments containing sildenafil or any other PDE5 inhibitors (such as Adcirca [tadalafil]). Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure. How should I take SILDENAFIL CITRATE TABLETS?

• Sildenafil citrate can also treat pulmonary arterial hypertension.
• It enhances exercise capacity in patients with this condition.
• The drug’s effects usually last 4-6 hours.
• Taking it with a high-fat meal can delay absorption.
• Sildenafil should not be used with nitrate medications.
• Serious side effects include vision changes and priapism.
• It is contraindicated in individuals with certain heart conditions.
• Patients should inform their doctor about all medications.

Take SILDENAFIL CITRATE TABLETS exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much SILDENAFIL CITRATE TABLETS to take and when to take it. Take SILDENAFIL CITRATE TABLETS about 1 hour before sexual activity. You may take SILDENAFIL CITRATE TABLETS between 30 minutes to 4 hours before sexual activity if needed.

• Sildenafil may interact with other medications, increasing risks.
• Significant interactions include nitrates and alpha-blockers.
• Patients should disclose all medications to their doctor.
• Combining with certain drugs can cause dangerous drops in blood pressure.
• Regular liver function monitoring may be necessary.
• Some herbal supplements also have interaction potential.
• Avoiding certain foods and medications reduces risks.
• Proper management improves treatment efficacy.

SILDENAFIL CITRATE TABLETS can be taken with or without food.

If you take SILDENAFIL CITRATE TABLETS after a high fat meal (such as a cheeseburger and french fries), SILDENAFIL CITRATE TABLETS may take a little longer to start working Do not take SILDENAFIL CITRATE TABLETS more than 1 time a day. If you accidentally take too much SILDENAFIL CITRATE TABLETS, call your doctor or go to the nearest hospital emergency room right away. What are the possible side effects of SILDENAFIL CITRATE TABLETS? SILDENAFIL CITRATE TABLETS can cause serious side effects. an erection that will not go away (priapism). sudden vision loss in one or both eyes. It is uncertain whether PDE5 inhibitors directly cause the vision loss. Stop taking SILDENAFIL CITRATE TABLETS and call your healthcare provider right away if you have sudden vision loss in one or both eyes. If you have these symptoms, stop taking SILDENAFIL CITRATE TABLETS and contact a doctor right away.

Notes et références

See the end of this leaflet for a complete list of ingredients in SILDENAFIL CITRATE TABLETS. What should I tell my healthcare provider before taking SILDENAFIL CITRATE TABLETS? Before you take SILDENAFIL CITRATE TABLETS, tell your healthcare provider if you: have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve or heart failure have had heart surgery within the last 6 months have low blood pressure, or high blood pressure that is not controlled have had an erection that lasted for more than 4 hours have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia have retinitis pigmentosa, a rare genetic (runs in families) eye disease have ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) have kidney problems or are having kidney dialysis Tell your healthcare provider about all the medicines you take1, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SILDENAFIL CITRATE TABLETS may affect the way other medicines work, and other medicines may affect sildenafil pink pill the way SILDENAFIL CITRATE TABLETS works causing side effects. Especially tell your healthcare provider if you take any of the following: medicines called nitrates (see "What is the most important information I should know about SILDENAFIL CITRATE TABLETS?") medicines called guanylate cyclase stimulators, such as riociguat (Adempas) medicines called alpha blockers such as Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosin mesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin).

Dosage for pulmonary arterial hypertension (PAH)

Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. In some patients, the use of SILDENAFIL CITRATE TABLETS with alpha-blockers can lead to a drop in blood pressure or to fainting. medicines called HIV protease inhibitors, such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase) or atazanavir sulfate (Reyataz) some types of oral antifungal medicines, such as ketoconazole (Nizoral), and itraconazole (Sporanox) some types of antibiotics, such as clarithromycin (Biaxin), telithromycin (Ketek), or erythromycin other medicines that treat high blood pressure SILDENAFIL CITRATE TABLETS contains sildenafil, which is the same medicine found in another drug called SILDENAFIL TABLETS. SILDENAFIL TABLETS is used to treat a rare disease called pulmonary arterial hypertension (PAH). SILDENAFIL CITRATE TABLETS should not be used with SILDENAFIL TABLETS or with other PAH treatments containing sildenafil or any other PDE5 inhibitors (such as Adcirca [tadalafil]).

Dosage for erectile dysfunction (ED)

Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure. How should I take SILDENAFIL CITRATE TABLETS? Take SILDENAFIL CITRATE TABLETS exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much SILDENAFIL CITRATE TABLETS to take and when to take it. Take SILDENAFIL CITRATE TABLETS about 1 hour before sexual activity. The most common side effects of SILDENAFIL CITRATE TABLETS are: abnormal vision, such as changes in color vision (such as having a blue color tinge) and blurred vision In addition, heart attack, stroke, irregular heartbeats and death have happened rarely in men taking SILDENAFIL CITRATE TABLETS. Most, but not all, of these men had heart problems before taking SILDENAFIL CITRATE TABLETS. It is not known if SILDENAFIL CITRATE TABLETS caused these problems. These are not all the possible side effects of SILDENAFIL CITRATE TABLETS. For more information, ask your healthcare provider 50 mg sildenafil price or pharmacist.

In case of emergency/overdose

You may take SILDENAFIL CITRATE TABLETS between 30 minutes to 4 hours before sexual activity if needed. SILDENAFIL CITRATE TABLETS can be taken with or without food. If you take SILDENAFIL CITRATE TABLETS after a high fat meal (such as a cheeseburger and french fries), SILDENAFIL CITRATE TABLETS may take a little longer to start working Do not take SILDENAFIL CITRATE TABLETS more than 1 time a day. If you accidentally take too much SILDENAFIL CITRATE TABLETS, call your doctor or go to the nearest hospital emergency room right away. What are the possible side effects of SILDENAFIL CITRATE TABLETS?

How should Sildenafil Citrate Tablets be stored?

SILDENAFIL CITRATE TABLETS can cause serious side effects. an erection that will not go away (priapism). sudden vision loss in one or both eyes. It is uncertain whether PDE5 inhibitors directly cause the vision loss. Stop taking SILDENAFIL CITRATE TABLETS and call your healthcare provider right away if you have sudden vision loss in one or both eyes.

Patient resources

If you have these symptoms, stop taking SILDENAFIL CITRATE TABLETS and contact a doctor right away. The most common side effects of SILDENAFIL CITRATE TABLETS are: abnormal vision, such as changes in color vision (such as having a blue color tinge) and blurred vision In addition, heart attack, stroke, irregular heartbeats and death have happened rarely in men taking SILDENAFIL CITRATE TABLETS. Most, but not all, of these men had heart problems before taking SILDENAFIL CITRATE TABLETS. It is not known if SILDENAFIL CITRATE TABLETS caused these problems. These are not all the possible side effects of SILDENAFIL CITRATE TABLETS. You may report side effects to FDA at 1-800-FDA-1088. How should I store SILDENAFIL CITRATE TABLETS? Store SILDENAFIL CITRATE TABLETS at room temperature between 68°F to 77°F (20°C to 25°C). Keep SILDENAFIL CITRATE TABLETS and all medicines out of the reach of children. General information about the safe and effective use of SILDENAFIL CITRATE TABLETS. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use SILDENAFIL CITRATE TABLETS for a condition for which it was not prescribed. Do not give SILDENAFIL CITRATE TABLETS to other people, even if they have the same symptoms that you have. This Patient Information leaflet summarizes the most important information about SILDENAFIL CITRATE TABLETS. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about SILDENAFIL CITRATE TABLETS that is written for health professionals. For more information, go to or call 1-800-438-1985 What are the ingredients in SILDENAFIL CITRATE TABLETS?

1. How it works

The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid 11,12,13,14,15,16,8,9.Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart - before being serendipitously indicated for treating erectile dysfunction in the late 1980s 7. Nevertheless, it is because of this mechanism that sildenafil is also indicated for treating pulmonary arterial hypertension but is also additionally notorious for interacting with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises 4,5,6.Regardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in the public in 1998 7, continues to see millions of prescriptions written for it internationally. Although the medication has historically been most popularly recognized as Pfizer's brand name Viagra, sildenafil is currently available generically and even as a non-prescription over the counter medication in some countries 10. This Patient Information has been approved by the U.S. Food and Drug Administration. This product's label may have been updated. For current full prescribing information, please visit Cardura (doxazosin mesylate), and Minipress (prazosin HCl) are registered trademarks of Pfizer Inc. The other brands listed are trademarks of their respective owners and are not trademarks of Pfizer Inc.

What happens if I overdose?

This product's label may have been updated. For current full prescribing information, please visit Cardura (doxazosin mesylate), and Minipress (prazosin HCl) are registered trademarks of Pfizer Inc. The other brands listed are trademarks of their respective owners and are not trademarks of Pfizer Inc. The makers of these brands are not affiliated with and do not endorse Pfizer Inc or its products. SildenafilIn eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) 11,12,13,14,15,16,8,9. The makers of these brands are not affiliated with and do not endorse Pfizer Inc or its products.

Before taking this medicine

SildenafilIn eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) 11,12,13,14,15,16,8,9. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid 11,12,13,14,15,16,8,9.Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart - before being serendipitously indicated for treating erectile dysfunction in the late 1980s 7. Nevertheless, it is because of this mechanism that sildenafil is also indicated for treating pulmonary arterial hypertension but is also additionally notorious for interacting with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises 4,5,6.Regardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in the public in 1998 7, continues to see millions of prescriptions written for it internationally. Although the medication has historically been most popularly recognized as Pfizer's brand name Viagra, sildenafil is currently available generically and even as a non-prescription over the counter medication in some countries 10.